PandaOmics Filters

Filtering

Druggability filters utilize traffic light logic to indicate the most crucial protein characteristics

Development level

Tclin
These targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
Tbio
These targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria:

(1) target is above the cutoff criteria for Tdark;

(2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
Tchem
These targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tdark
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy two or more of the following criteria:

(1) A PubMed text-mining score from Jensen Lab < 5;

(2) <= 3 Gene RIFs;

(3) <= 50 Antibodies available according to http:antibodypedia.com.

Small molecules

Indicates accessibility of a protein by small molecules

If the target does not belong to druggable protein classes and has no small molecules for it
If the target does belong to druggable protein classes and has no small molecules for it
If there is information about target druggability from at least one of informational sources: Clinical trials, TTD, Open Targets platform, TCRD (drug activity count and drug central activity count)

Antibodies

Indicates the ability to use antibodies to hit the target

If the target is not membrane secreted (Protein atlas database)
If the target is membrane secreted (Protein atlas database)
If the target is membrane secreted (Protein atlas database) and there are antibodies in TCRD database

Safety

Potential safety of a target and potential adverse effects

If the target is an essential gene and did not pass any clinical trials (Clinical trials and TTD)
Default setting for safety filter (Clinical trials and TTD)
If the target is a conditional essential gene or is not essential and has clinical trials going on or passed (Clinical trials and TTD)

Novelty

Indicates the overall scientific community interest to the target, based on the volume of related publications proposed by the proprietary AI engine

PHARMA.AI