Filtering
Druggability filters utilize traffic light logic to indicate the most crucial protein characteristics
Development level
Tclin
These targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
Tbio
These targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria:

(1) target is above the cutoff criteria for Tdark;

(2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
Tchem
These targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tdark
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy two or more of the following criteria:

(1) A PubMed text-mining score from Jensen Lab < 5;

(2) <= 3 Gene RIFs;

(3) <= 50 Antibodies available according to http:antibodypedia.com.
Small molecules
Indicates accessibility of a protein by small molecules
If the target does not belong to druggable protein classes and has no small molecules for it in the database_x
If the target does belong to druggable protein classes and has no small molecules for it in the database_x
If there is information about target druggability from at least one of informational sources: database_x, clinical trials and TTD, Open Targets platform, TCRD(drug activity count and drug central activity count)
Antibodies
Indicates the ability to use antibodies to hit the target
If the target is not membrane secreted (Protein atlas database)
If the target is membrane secreted (Protein atlas database)
If the target is membrane secreted (Protein atlas database) and there are antibodies in tcrd database
Safety
Potential safety of a target and potential adverse effects
If the target is an essential gene and did not pass any clinical trials (Clinical trials and TTD)
Default setting for safety filter (Clinical trials and TTD)
If the target is a conditional essential gene or is not essential and has clinical trials going on or passed (Clinical trials and TTD)
Novelty
Indicates the overall scientific community interest to the target, based on the volume of related publications proposed by the proprietary AI engine
More than 168 publications on pharmacognitive
168 publications or less on pharmacognitive
Less than 49 publications on pharmacognitive