"From AI-powered target discovery based on massive datasets, to biological validation by multiple model systems (fly, mouse, human iPS cells), to rapid clinical testing throughinvestigator-initiated trials
(IIT), the represents a new trend that may dramatically reduce the costs and duration and more importantly the success rate of developing medicines, especially for neurodegenerative diseases" said Bai Lu, Professor at Tsinghua University and Founder of 4B Technologies. "We are very happy to be part of this international team, and very excited about the subsequent efforts to clinically validate these novel targets."
"We are truly excited to see the Answer ALS data being used to identify possible ALS disease-causing pathways and candidate drugs," said Jeffrey D. Rothstein MD, PhD, Director, Robert Packard Center for ALS Research and Answer ALS. "The work by Insilico is exactly how this unprecedented program was envisioned to help change the course of ALS."
"It is exciting to see the power of AI to help understand ALS biology," said Merit Cudkowicz, MD, Chief of Neurology and Director of the Healey & AMG Center for ALS at Mass General Hospital and Harvard Medical School and corresponding author. "Through Sean Healey and his friends, I was introduced to Dr. Zhavoronkov and the Insilico team. We immediately saw the potential to connect the Insilico team with the multidisciplinary Answer ALS team. We look forward to the next steps to turn this knowledge into new targets for treatments for people living with ALS."