Affected Pathways

Differentially expressed genes are calculated using the Pandomics's proprietary iPANDA method
Ozerov, I., Lezhnina, K., Izumchenko, E. et al. In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development. Nat Commun 7, 13427 (2016).
The chart represents the grouping of Reactome pathways by the high-level processes affected. Each bar represents the total number of process related pathways divided in three groups:
  • Significantly activated pathways
  • Significantly inhibited pathways
  • Pathways which activity change is not statistically significant across all samples in the case group
Heatmap visualization located below the list of pathways, allows you to assess pathway activation/inhibition across all the samples in the case group